Manchester United are likely to be without injured forwards Anthony Martial and Marcus Rashford, so Mason Greenwood, 17, may start his first league game this season.
Midfielder Paul Pogba is a doubt because of an ankle problem he picked up against Rochdale, but left-back Luke Shaw is back in training.
Arsenal striker Alexandre Lacazette is ruled out with an ankle injury.
Dinos Mavropanos is available for selection after a groin problem.
Emile Smith Rowe is sidelined by concussion, but Rob Holding, Hector Bellerin and Kieran Tierney are all fit, with the latter available to make his Premier League debut.